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Phase 2 data reported roughly 10-11% weight loss versus placebo at ~26 weeks as a monotherapy example, and Phase 3 CagriSema data reported substantially larger reductions when combined with semaglutide

Tirzepatide activates two receptor systems simultaneously

The key feature of these TJs is to restrict the permeation of macromolecules, ions, and other polar solutes through paracellular diffusional pathways [1, 21]